September Monthly Meeting
Spectroscopy Society of Pittsburgh September Meeting
WHEN: Wednesday – September 18, 2013
WHERE: Duquesne University – Mellon Hall (Laura Lecture Hall)
RSVP BY: Wednesday – September 11, 2013
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TECHNOLOGY FORUM – 5:30PM
Roger A. Howell, Alpha Aromatics
“Understanding Fragrance – It’s Origin and History”
(Description to follow)
TECHNICAL PROGRAM –
8:15 PM
Dr. Laurence Nafie, Syracuse University
“Reflections on the Pittsburgh Spectroscopy Award and Vibrational Optical Activity”
Dr. Nafie will
present highlights and other observations of his Pittcon award address. Both IR and Raman forms of vibrational optical activity (VOA) were discovered experimentally nearly 40 years ago [1]. The IR form is vibrational circular dichroism (VCD) and the Raman form is Raman optical activity (ROA). For the first 20 years of VOA, VCD and ROA passed through a
period of gradual growth spearheaded by a few academic laboratories. Then, in mid-1990s, two developments occurred for VCD, followed a few years later for ROA. These were the commercial availability of instrumentation for measurements and software for calculations. The comparison of measured and calculated VOA yields new insights into the absolute structure and conformation of chiral molecules.
In the past 15 to 20 years VOA has undergone a period of rapid growth and maturation. Hundreds of scientists in both academic laboratories and pharmaceutical companies
now use VOA on a regular basis to explore its depth of molecular information and to solve stereochemistry problems of practical importance. Academic labs use VOA primarily to determine the conformation of biological molecules and to explore the effects of solvents and anharmonicity using computed VOA. Pharmaceutical companies use VOA to determine the absolute configuration of new chiral drug substances and to probe the higher order structure of biopharmaceutical molecules.
In this presentation, the extent of the routine use of VCD to determine absolute configuration of pharmaceutical and natural product molecules will be described as well as the use of VCD to reveal the underlying supramolecular chiral structure of amyloid
fibrils of interest in relation to the incidence of neurological diseases.
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