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Technical Program
Neil L. Kelleher, PhD
Walter and Mary Glass Professor of Molecular Biosciences and Professor of Chemistry
Weinberg College of Arts and Sciences
“The Case to Scale Proteoform Measurement and Biology to The Entire Human Proteome “
For over twenty years, the Kelleher Group has invented new methods to discover the exact forms of protein molecules in human cells. The world has come to call these “proteoforms” and Kelleher uses so-called “Top-Down” Proteomics to discover, characterize and assign function to them with increasing efficiency. With >350 papers, Dr. Kelleher is a cross-disciplinary investigator with international impact in proteomics (the study of proteins). Together with colleagues in a research consortium (https://www.topdownproteomics.org/), this emerging approach to measure proteins with complete molecular specificity is being advanced to improve the detection and assignment of function to protein modifications and complexes. Kelleher has mentored 52 Ph.D. students, >200 postdoctoral scholars, and >200 undergraduates. After a breakthrough Nature paper in 2011, Kelleher has continued to push the boundaries of proteomics and is currently advancing a compositional map of proteins in all cell types of the human body. This “domestication” of the human proteome via precise compositional mapping will improve the efficiency of basic and clinical research and therefore enhance diverse goals for the 21st Century, including designer organs, personalized medicine, and early detection of human disease. A recent article in Science (2022, 375: 411-418) typifies the promise and crescendo of activity in the area of proteomics, advanced consistently by Kelleher over the past 25 years.
Attend In-Person
The monthly meeting will be held in the Power Center Ballroom, Duquesne University. Registration for dinner is required.
Please pay for your meal with cash at the time of the meeting.
$5 for students; $15 for all others.
6:00 pm – Dinner
6:45 pm – Business Meeting
7:15 pm – Technical Program
Attend Virtually
The monthly meeting Technical Program is accessible via the Zoom platform.
Pre-registration required. Link will be emailed.
6:45 pm – Business Meeting
7:15 pm – Technical Program
PARKING: Duquesne University Parking Garage entrance is on Forbes Avenue. The Power Center can be accessed from the 8th Floor of the Forbes Garage. Bring your parking ticket to the dinner or meeting for a validation sticker.If there is a special event, please note that you are there for the SACP/SSP meeting.
About the Program Speaker
Neil L. Kelleher, PhD is the Walter and Mary Glass Professor of Molecular Biosciences and professor of chemistry in the Weinberg College of Arts and Sciences. He also is director of the 50-person Proteomics Center of Excellence, Director of the Chemistry of Life Processes and a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. His research is focused in the areas of top-down proteomics, natural products discovery, and cancer biology. With >450 papers, Dr. Kelleher is a cross-disciplinary investigator with international impact in proteomics (the study of proteins). Together with colleagues in a research consortium (https://www.topdownproteomics.org/), this emerging approach to measure proteins with complete molecular specificity is being advanced to improve the detection and assignment of function to protein modifications and complexes. Now with an H-index of 90, Kelleher has mentored over 52 Ph.D. students, >200 postdoctoral scholars, and >200 undergraduates. After a breakthrough Nature paper in 2011, Kelleher has continued to push the boundaries of proteomics, most recently culminating in a publication in Science (2022, 375: 411-418). Perspectives published by Kelleher and a consortium of like-minded researchers over the last decade articulating the value of proteoforms and a landmark project to map all proteoforms in the human body (Sci. Adv. 2021, 7: eabk0734) typify their thought leadership in a field seeing a new crescendo of interest and activity in the 2020s. This “domestication” of the human proteome via precise compositional mapping will improve the efficiency of basic and clinical research and therefore enhance diverse goals for the 21st Century, including designer organs, personalized medicine, and early detection of human disease.