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Technical Program
Prof. David C. Muddiman
Distinguished Professor of Chemistry and Founding Director, Molecular Education, Technology and Research Innovation Center (METRIC)
North Carolina State University
“Controlling Chaos: A Novel Molecular Microscopy Platform with Diverse Applications in Human Health and Disease”
Since its first demonstration in the 1960’s, the field of mass spectrometry imaging (MSI) has emerged as a fruitful area of scientific research with significant impacts to human health. To date, SIMS, MALDI, and DESI have been the primary ionization methods utilized in the field and these approaches have resulted in key new findings for a diverse range of biological questions. However, other emerging ionization methods have great potential to impact the field of MSI. We invented matrix-assisted laser desorption electrospray ionization (MALDESI) in 2005 and over the past 20 years, we have made tremendous progress in the fundamentals, source development, and demonstrated the principal advantages of this ionization technique over other methods and these will be discussed.
Mass spectrometry imaging offers a versatile and robust platform to discover and characterize new diagnostic, prognostic, and therapeutic biomarkers for disease, elucidate and understand biochemical pathways, visualize and quantify endogenous and exogenous compound distributions in tissues and characterize post-translational modifications (e.g., N-linked glycans). Moreover, a multi-omic approach will allow the underlying biology to be more accurately defined, enabling modeling of pathways and identify potential drug targets. The second part of this presentation will present a diverse range of biological questions which are made possible by innovations in our platform and the extensive use of isotopologues. The fundamentals and innovations of each strategy will be integrated throughout for each biological question being presented. Finally, biophysical studies will be presented demonstrating the versatility of the platform.
Attend In-Person
The monthly meeting will be held in the Power Center Ballroom, Duquesne University. Registration for dinner is required.
Please pay for your meal with a credit card at the time of the meeting.
$5 for students; $15 for all others.
6:00 pm – Dinner
6:45 pm – Business Meeting
7:30 pm – Technical Program
Attend Virtually
The monthly meeting Technical Program is accessible via the Zoom platform.
Pre-registration required. Link will be emailed.
6:45 pm – Business Meeting
7:30 pm – Technical Program
Please Note: No Parking Before 5:00 PM
There are new Duquesne University parking restrictions now in effect.
- Entry only AFTER 5:00 pm for all members, staff, students, and guests using the Forbes Avenue garage.
- Entry before 5:00 pm is limited to ONLY those involved with set-up in the Powers Center.
- Bring the QR parking ticket to the meeting for a paid QR ticket to scan when leaving the garage.
- The dinner registration form will ask you to indicate if you require a parking pass. Please note: passes are non-refundable and only valid for that meeting.
About the Program Speaker
